POLYMERIC HYDROGEL LABELED WITH RADIONUCLIDE AND LOADING ANGIOGENESIS-PROMOTING PROTEIN OR PEPTIDE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASE CONTAINING SAME AS ACTIVE INGREDIENT

摘要

The present invention relates to a polymeric hydrogel labeled with radionuclide and loading an angiogenesis-promoting protein or peptide, a method for preparing the same, and a pharmaceutical composition for preventing or treating ischemic disease containing the same as an active ingredient. In the polymeric hydrogel according to the present invention, a biodegradable polymer is directly labeled with radionuclide and an angiogenesis-promoting protein or peptide is loaded thereon at the time of forming the hydrogel, so that the polymeric hydrogel can slowly release the angiogenesis-promoting protein or peptide while staying at the polymeric hydrogel-integrated lesion site, thereby preventing the waste of a large quantity of angiogenesis-promoting protein, and can confirm the in vivo distribution using a gamma camera, thereby quantifying the amount of particles staying at the site of ischemic disease and allowing the prediction of the treatment effect. In addition, the polymeric hydrogel according to the present invention can be favorably used in the treatment of disease, such as ischemic disease, by emitting radiation to the lesion site. Therefore, the polymeric hydrogel according to the present invention enables the expectation of treatment effects by both the radionuclide and the angiogenesis-promoting protein or peptide and can quantitatively estimate the accumulation of therapeutic agents, thereby increasing the treatment effect on the lesion.