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Cell-derived viral vaccines with low levels of residual cell dna
Cell-derived viral vaccines with low levels of residual cell dna
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机译:残留细胞DNA含量低的细胞源性病毒疫苗
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摘要
The present invention relates to vaccine products for the treatment or prevention of viral infections. Further provided are methods of reducing contaminants associated with the preparation of cell culture vaccines. Residual functional cell culture DNA is degraded by treatment with a DNA alkylating agent, such as β-propiolactone (BPL), thereby providing a vaccine comprising immunogenic proteins derived from a virus propagated on cell culture, substantially free of residual functional cell culture DNA.
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