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MONITORING CLONOTYPES OF PLASMA CELL PROLIFERATIVE DISORDERS IN PERIPHERAL BLOOD
MONITORING CLONOTYPES OF PLASMA CELL PROLIFERATIVE DISORDERS IN PERIPHERAL BLOOD
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机译:外周血中血浆细胞增殖性疾病的监测型
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摘要
The invention is directed to sequencing-based methods for monitoring a minimal residual disease of a plasma cell proliferative disorder, such as multiple myeloma and/or MGUS, by one or more clonotypes correlated with the disorder. In some embodiments, such methods comprise the following steps: (a) obtaining a sample of peripheral blood from the patient; (b) amplifying molecules of nucleic acid from the sample, the molecules of nucleic acid comprising recombined DNA sequences from immunoglobulin genes; (c) sequencing the amplified molecules of nucleic acid to form a clonotype profile; and (d) determining from the clonotype profile a presence, absence and/or level of one or more patient-specific clonotypes correlated with the plasma cell proliferative disorder and phylogenic clonotypes thereof.
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