THE PRODUCTS CONTAINING PROBIOTIC LACTOBACILLUS ACIDOPHILUS HY7037 HAVING ACTIVITY PREVENTING FROM INSULIN RESISTANCE, WHICH CAUSED TYPE 2 DIABETES MELLITUS

摘要

The present invention relates to Lactobacillus acidophilus HY7037 having an effect of improving insulin resistance and a product containing the same as an active ingredient. Lactobacillus acidophilus HY7037 according to the present invention can improve an insulin resistance inducing environment by primarily increasing the glucose uptake reduced by TNF-, increases gene and protein expressions of GLUT4 involved in the glucose uptake, increasing protein phosphorylation of AKT and IRS(Tyr)-1 of the insulin signal pathway influencing translocation and expression of GLUT4, and increasing the expression levels of PPAR and PGC-1 known to be involved in insulin sensitivity, in L6 skeletal muscle cells of rats having insulin resistance induced by TNF-, and can improve an insulin resistance environment which is mainly caused by type 2 diabetes by reducing the gene level of IL-6 increased by TNF-, which is a kind of inflammatory cytokine, and thus can be variously used for a pharmaceutical composition for preventing and treating metabolic syndrome, a functional health food, a functional beverage, a fermented product, and the like.