Albumin nanoparticles containing poorly water soluble drugs and its preparation method and application thereof

摘要

the present invention is to mediate in vivo delivery via solubilization and stabilization of the aqueous solution poorly water-soluble drugs can be made with a non-peptide polymer and albumin nanoparticle aggregate method that includes therein, in particular because it uses only the organic solvent even though the non-peptide polymer and the poorly water-soluble albumin aggregates and co-dissolution of the drug can be Even if not use a separate chemical or physical action of the two components are mixed there is a feature that will be done well. In addition, polyethylene glycol and albumin according to the invention once-polymer nanoparticle manufacturing method is a surfactant, does not contain a solubilizing agent, poorly water-soluble drug does not cause sensitization reactions or toxicity of the formulation by increasing the adherence of the patient at the same time may have advantages. In addition, a variety of poorly water-soluble drugs, as well as stabilization of the image and / inorganic nano-particles may also be used for diagnostic purposes is useful. ;