首页> 外国专利> METHOD FOR SCREENING FORMULATION USED FOR PREVENTING OR TREATING DISEASES RELATED TO FGF2 INCLUDING CLONE MYELOBLASTIC CELLUAR DISEASES

METHOD FOR SCREENING FORMULATION USED FOR PREVENTING OR TREATING DISEASES RELATED TO FGF2 INCLUDING CLONE MYELOBLASTIC CELLUAR DISEASES

机译:预防或治疗与FGF2相关的疾病的筛查制剂的方法,包括与成年骨髓细胞性疾病

摘要

The present invention relates to a method for screening formulations used for preventing or treating diseases related to FGF2, which comprises a step of measuring the level of CXCL5 in cells for making bones and vascular endothelial cells processed with FGF2 and candidate materials to prevent or treat diseases related to FGF2 including clone myeloblastic cellular diseases, a screening kit used in the screening method and a formulation obtained by the screening method for treating or preventing diseases related to FGF2. In the present invention, using the screening method is allowed to easily screen the formulation with a high reliability wherein the formulation is used for treating or preventing diseases related to bones caused by excesses FGF2 and other diseases related to hematopoietic stem cells like an effect on movement of hematopoietic stem cell series in bone marrow by the change of bone, thereby being used for manufacturing drugs to treat or prevent diseases related to FGF2 or to hematopoietic stem cell series.;COPYRIGHT KIPO 2015
机译:本发明涉及一种筛选用于预防或治疗与FGF2有关的疾病的制剂的方法,该方法包括测量用于制备经FGF2处理的骨骼和血管内皮细胞的细胞以及预防或治疗疾病的候选材料中CXCL5水平的步骤。与FGF2相关的疾病,包括克隆性成肌细胞疾病,用于该筛选方法的筛选试剂盒以及通过该筛选方法获得的用于治疗或预防与FGF2有关的疾病的制剂。在本发明中,允许使用筛选方法以高可靠性容易地筛选制剂,其中该制剂用于治疗或预防由过量的FGF2引起的与骨骼有关的疾病和与造血干细胞有关的其他疾病,例如对运动的影响。骨骼变化对骨髓中造血干细胞系列的研究,从而用于制造用于治疗或预防与FGF2或造血干细胞系列相关的疾病的药物。; COPYRIGHT KIPO 2015

著录项

  • 公开/公告号KR20150025697A

    专利类型

  • 公开/公告日2015-03-11

    原文格式PDF

  • 申请/专利权人 SNU R&DB FOUNDATION;

    申请/专利号KR20130103648

  • 发明设计人 CHO JE YOELKR;YOON KYUNG AEKR;

    申请日2013-08-30

  • 分类号C12Q1/68;G01N33/68;C12N15/11;

  • 国家 KR

  • 入库时间 2022-08-21 15:00:33

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