Recombinant adenovirus expressing rabies virus gene and vaccine composition for preventing or treating rabies comprising the same

摘要

The present invention relates to a recombinant adenovirus expressing a rabies virus gene and a vaccine composition for preventing or treating rabies comprising the same. The recombinant adenovirus according to the present invention, which is a recombinant virus of nucleotide sequences coding G protein and N protein of the rabies virus isolated from the country, effectively expresses G protein and N protein of the rabies virus and has a proliferation ability suitable for the use as a vaccine strain, and thus is suitable in mass production thereof. Further, the present invention has improved stability as compared with the exiting vaccine and thus can be used for oral administration, and has excellent ability to defend against the rabies virus at the time of vaccination.