The present invention relates to a composition for estimating the risk of onset of systemic lupus erythematosus, and more particularly, to a composition which determines an examinee as having a high risk of onset of systemic lupus erythematosus when a DNA copy number variation has occurred in the C4 region, 1q25.1 region and 10q21.3 region. The composition of the present invention may estimate the risk of onset of systemic lupus erythematosus using the fact that the copy number variation in C4 location, 1q25.1 location and 10q21.3 location has a synergistic effect in the occurrence of systemic lupus erythematosus. The composition of the present invention enables a clinically friendly method that may reduce an error of an analysis which might be caused by a newly purchased device or by technological limitations, by using PCR which is generally performed in most laboratories of hospital. Furthermore, the composition of the present invention has the advantages of being performed on an examinee using a non-invasive method. Thus, the composition of the present invention may estimate the risk of onset of systemic lupus erythematosus at an early stage, and thus can be used in preventing an aggravated state or in delaying the occurrence of the disease.
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