AMPHIPHILIC BLOCK COPOLYMER CONTAINING siRNA AS A HYDROPHILIC BLOCK AND POLYION COMPLEX CONTAINING THE SAME

摘要

The present invention relates to an amphiphilic block copolymer having a nucleic acid molecule as a hydrophilic block, a method for producing the same, a polyion composite including the amphiphilic block copolymer and a cationic carrier, a self-assembly including the polyion composite, and a composition for carrying nucleic acids, including the self-assembly. More particularly, a nucleic acid molecule is contained as a hydrophilic block so that charge density and flexibility are increased and a polyion composite can be effectively produced thereby. A hydrophilic block is induced to cause a hydrophilic interaction so that a cationic carrier and a compact and stable polyion composite are produced and an intracellular delivery effect can be improved.