首页> 外国专利> Biomarker composition for predicting progress from colorectal adenoma to carcinoma of human patients and biokit for dyagnosis thereof comprising the same

Biomarker composition for predicting progress from colorectal adenoma to carcinoma of human patients and biokit for dyagnosis thereof comprising the same

机译:预测人类患者从大肠腺瘤发展为癌的生物标志物组合物及其诊断试剂盒

摘要

The present invention Bio Protein can predict the progression of colorectal cancer in the colon polyps and relates to a colon cancer marker diagnostic kit comprising a bio-cytokine plasma biomarkers, specifically a leucine-rich -2-glycoprotein (LRG), hemoglobin subunit (HBB), Ig -2 chain C region (IgA2C), complement factor B (CFB), afamin, zinc- -2-glycoprotein (ZAG), vitronectin (VTN), 1-antichymotrypsin (AACT) comprising at least one or more proteins from colon polyps - colorectal cancer progression on the prediction and diagnosis kit that the LRG, HBB, IgA2C, CFB protein is increased in cancer patients, afamin, ZAG, VTN, AACT proteins that have different characteristics from colorectal cancer patients and also reduce cytokine or chemokine is IL-8, IP-10 , TNF- is diagnosed to accurately distinguish the progress of the colon the proteins can be used as a marker to predict the progression of colorectal cancer in colon polyp of the 8 species and is characterized by increased in colon cancer patients in early There are excellent results that can be. ;
机译:本发明的生物蛋白可以预测结肠息肉中结肠直肠癌的进展,并且涉及一种结肠癌标志物诊断试剂盒,其包括生物细胞因子血浆生物标志物,特别是富含亮氨酸的-2-糖蛋白(LRG),血红蛋白亚基(HBB)。 ),Ig -2链C区(IgA2C),补体因子B(CFB),afamin,锌-2-糖蛋白(ZAG),玻连蛋白(VTN),1-抗胰凝乳蛋白酶(AACT),包含至少一种或多种蛋白质结肠息肉-结肠直肠息肉预测和诊断试剂盒上的结直肠癌进展,表明癌症患者中的LRG,HBB,IgA2C,CFB蛋白增加,afamin,ZAG,VTN,AACT蛋白具有与结直肠癌患者不同的特征,并且还降低了细胞因子或趋化因子被诊断为IL-8,IP-10,TNF-α,可准确区分结肠的进展。该蛋白可用作标记物,以预测8种结肠息肉中结肠直肠癌的进展,其特征是结肠的增加C早期癌症患者可以取得出色的结果。 ;

著录项

  • 公开/公告号KR1015126780000B1

    专利类型

  • 公开/公告日2015-04-17

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR1020140082120

  • 发明设计人 윤종원;최정원;

    申请日2014-07-01

  • 分类号C07K14/47;G01N33/574;G01N33/68;

  • 国家 KR

  • 入库时间 2022-08-21 14:58:21

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