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poly-glutamic acid taxane conjugates from conjugated taxane in an amount determined how

机译：共轭紫杉烷中的多谷氨酸紫杉烷共轭物的含量决定了

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摘要

This invention relates to a method for determining the amount of taxanes, in particular paclitaxel taxane conjugate junction PGA- relates, the method comprising: A) PGA-taxane conjugate with the general formula ( I to produce unbound reacting the compound of) taxanes: R ¹ R ² N-NH ₂ (I), wherein R ¹ and R ² are as defined in the description; And, b) it includes determining the amount of unbound taxane. ; PGA-taxane conjugate, paclitaxel, quantitative

机译：本发明涉及一种测定紫杉烷类化合物的量的方法，特别是涉及紫杉醇紫杉烷类共轭物的PGA-涉及，该方法包括：A）具有通式（ I ）的PGA-紫杉烷类共轭物以产生未结合的反应紫杉烷类化合物：R ^{1 R ^{2 N-NH _{2 （I），其中R ^{1 和R ^{2 如描述中所定义;并且，b）包括确定未结合的紫杉烷的量。 ; PGA-紫杉烷共轭物，紫杉醇，定量}}}}} 展开▼

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公开/公告号KR1015148330000B1

专利类型

公开/公告日2015-04-24

原文格式PDF

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申请/专利号KR1020097018559

发明设计人 스푸네모어 홀리;시비에로 루이기;맥케논 마크;호브다 케이쓰;파지오니 스테파노;리비 발레리아;
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申请日2008-03-05

分类号A61K33/24;G01N30/22;G01N33/15;G01N33/50;G01N33/68;

国家 KR

入库时间 2022-08-21 14:58:15

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中文文献

1. 确定聚谷氨酸-紫杉烷结合物中结合的紫杉烷的量的方法 [P] . 中国专利： CN101641598B . 2014.09.24

2. 确定聚谷氨酸－紫杉烷结合物中结合的紫杉烷的量的方法 [P] . 中国专利： CN101641598A . 2010-02-03

3. METHOD FOR DETERMINING THE AMOUNT OF CONJUGATED TAXANE IN POLYGLUTAMIC ACID-TAXANE CONJUGATES [P] . CA2680073C . 2016-04-19

机译：测定聚葡萄糖酸-X杂共轭物中共轭T烷含量的方法

4. METHOD FOR DETERMINING THE AMOUNT OF CONJUGATED TAXANE IN POLYGLUT ACID-TAXANE CONJUGATES [P] . IN269584B . 2015-10-30

机译：聚丙烯酰胺酸-X杂共轭物中共轭T烷含量的测定方法

5. Method for determining the amount of conjugated taxane in a polyglutamic acid-taxane conjugate [P] . 日本专利： JP5133357B2 . 2013-01-30

机译：测定聚谷氨酸-紫杉烷共轭物中的共轭紫杉烷量的方法

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8. BMET-23ANG1005 A NOVEL BRAIN-PENETRANT PEPTIDE-TAXANE CONJUGATE FOR THE TREATMENT OF CNS METASTASES FROM BREAST CANCER [O] . Priya Kumthekar, Susan Bates, Santosh Kesari, 2015

9. BMET-23ANG1005, A NOVEL BRAIN-PENETRANT PEPTIDE-TAXANE CONJUGATE, FOR THE TREATMENT OF CNS METASTASES FROM BREAST CANCER [O] . Priya Kumthekar, Susan Bates, Santosh Kesari, 2015

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