PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF HIPPOPHAE RHAMNOIDES L． LEAF AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME

摘要

The present invention relates to a pharmaceutical composition and a health functional food for the prevention or treatment of thrombosis which contains vitamin Hippophae rhamnoides L. leaf extract as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating thrombosis, , A pharmaceutical composition for preventing or treating thrombosis, which contains, as an effective ingredient, an ethyl acetate fraction or a water residue after an organic solvent fraction of an ethanol extract of a vitamin tree leaf, and a health functional food comprising the extract or the fraction. The pharmaceutical composition for the prevention or treatment of thrombosis according to the present invention and the vitamin tree leaf extract as an active ingredient of the health functional food can be prepared by extracting vitamin tree leaves with ethanol or the like to prepare an extract Ethyl acetate fractions and water residues exhibiting antithrombotic activity due to the excellent anticoagulant effect are effective to inhibit thrombogenesis efficiently. The anticoagulant activity of the anticoagulant, There is an excellent effect that can be used for prevention and treatment of thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation. In particular, the vitamin tree leaf extract of the present invention is free from acute oral toxicity, has no human erythropoietic activity, has excellent thermal stability, and is capable of inhibiting direct inhibition of human thrombin, prothrombin inhibition, blood coagulation factor inhibition It is an extremely useful invention in the pharmaceutical industry and the food industry because it can be prepared in various forms such as extract, powder, ring, and tablet, and can be prepared at any time.