PHARMACEUTICAL COMPOSITION COMPRISING THE ORGANIC SOLVENT FRACTION YIELDED FROM HOT WATER EXTRACTION OF LAMINARIA JAPONICA AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME

摘要

The present invention relates to a pharmaceutical composition and a health functional food for preventing or treating thrombosis containing an organic solvent fraction obtained from a hot water extract of seaweed ( Laminaria japonica ) as a brown algae as an active ingredient, and more particularly, A pharmaceutical composition for the prevention or treatment of thrombosis and a health functional food containing the fraction of at least one of hexane fraction, ethyl acetate fraction and butanol fraction which are successively fractionated from a hot-water extract of the present invention as an active ingredient. The pharmaceutical composition for the prevention or treatment of thrombosis according to the present invention and the organic solvent fraction obtained from the hot water extract of kelp as an active ingredient of the health functional food can be obtained by extracting the kelp by hot water extraction, The hexane fraction, the ethyl acetate fraction and the butanol fraction thus prepared had excellent thrombin inhibitory effect and antithrombotic activity by the effect of inhibiting the blood coagulation factor, And there is an excellent effect that can be used for prevention and treatment of thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation. Particularly, the organic solvent fractions obtained by successive fractionation from the hot water extract of sea tangle according to the present invention are excellent in thermal stability, and do not exhibit the direct inhibition of human thrombin or inhibition of blood coagulation factor even in an acidic condition of pH 2 and plasma, Powder, ring, tablet, etc., and can be prepared in a form that can be taken at any time. Therefore, it is an extremely useful invention in the pharmaceutical industry and the food industry.