Screening method for candidate drugs for Huntington's disease using induced pluripotent stem cells derived from Huntington's disease patients

摘要

The present invention relates to an induced pluripotent stem cell (HD-iPSC) derived from a Huntington's disease patient. Also, it was confirmed that Huntington biomarker was expressed when it was treated under specific conditions when it was subdivided into cells or when it was differentiated into neurons. The HD-iPSC can be useful for screening a therapeutic agent for Huntington's disease through the change of the biomarker, and the HD-iPSC can be effectively used as an autologous cell therapy agent of Huntington's disease if the genetic defect is removed have.