The present invention relates to a composition for preventing, treating or ameliorating TRPV1 (Transient Receptor Potential channel, Vanilloid subfamily member 1) -mediated disease, which comprises an extract of Lactuca raddeana as an active ingredient. The composition of the present invention is a composition which is extracted from a natural plant material and which has no side effects on the human body. The composition provides prevention, treatment or improvement of pain and inflammation.
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