pH pH sensitive lipopeptide containing composite of polyhistidine and phospholipid and process for preparing the same

摘要

The present invention is pH-sensitive lipid-peptide containing a combination of poly-histidine and phospholipids It relates to. Lipid peptide according to the present invention is to load the various drugs sikimyeo slowly release the drug over time by containing a combination of polyhistidine and phospholipids, due to the pH sensitive exhibits high cytotoxic at slightly acidic environment, optionally in the cells of a weak acid and effectively it acts to be useful as a drug delivery system can be used for a particular disease having an environmental change in a weak acid condition. In particular, it can act on cancer cells and tumor specific to be useful as anti-cancer agents. ;