Methods for Predicting or Determining Arterial Stiffness Using plasma metabolites

摘要

(A) obtaining a sample containing blood separated from a subject; (18: 2/18: 2) and lysophosphatidylcholine (18: 2) in the sample, and (b) the L-leucine, palmitic amide, L-octanoyl carnitine, decanoyl carnitine, lactosylceramide, And a method for providing information necessary for diagnosis or prognosis of cardiovascular complications including the step of measuring the concentration of a plasma metabolite selected from the group consisting of the group consisting of According to the present invention, there is provided a method for producing a plasma of a plasma selected from the group consisting of L-leucine, palmitic amide, L-octanoyl carnitine, decanoyl carnitine, lactosylceramide and phosphatidylcholine (18: 2/18: 2) The concentration of the metabolite was positively correlated with the blood vessel stiffness, and the lyso-phosphatidylcholine (18: 2) had a negative correlation with the blood vessel stiffness, so that the plasma metabolite having the above- A low concentration of plasma metabolites with negative correlations increases the risk of cardiovascular complications due to high vascular stiffness. Therefore, the method of the present invention has an effect of being useful for diagnosis of cardiovascular complications by determining the blood vessel stiffness by analyzing the values of the concentrations and parameters of various plasma metabolites in an overweight subject.