MURINE THE MODEL OF PULMONARY C BY DELETION IL33 OF THE N- END OF THE DOMAIN

摘要

1. The animal is not a human, with a deletion in the N-end of the IL-33.2 gene. Animal, non-human, of claim 1, wherein in the N-end of the IL-33 gene is completely deleted binding domain DNK.3. Animal, not a person under paragraphs 1 or 2, wherein the animal, not a person - it mlekopitayuschee.4. Animal, not a person, according to claim 3, wherein the animal, not a person - it gryzun.5. Animal, non-human, according to claim 4, wherein the animal, non-human, - a mouse and wherein a deletion in the N-end of the gene IL-33 is a deletion of 1-67 amino acids in IL-33.6 gene product expression. Descendant of the animal, non-human, the points 1 to 5, obtained by crossbreeding animals with the same or different genotipa.7. cell line or primary culture cells obtained from the animal, non-human, the points 1 to 5, or from a progeny of item 6.8. Explant tissue or organ, or derived from the culture obtained from the animal, non-human, the points 1 to 5 or a descendant of section 6.9. The use of an animal, not a person, in any one of claims 1 to 5, as a model of inflammatory zabolevaniy.10. Application descendant of claim 6 in a model of inflammatory zabolevaniy.11. Use of a cell line or primary cell culture according to claim 7 as a model of inflammatory zabolevaniy.12. Use of tissue or organ explant of claim 8 as a model of inflammatory zabolevaniy.13. Use according to any one of p.p.9-12 for selecting anti soedineniy.14. Use according to any one of p.p.9-12 for evaluation of the pharmacological action of anti-inflammatory soedineniya.15. The method of selection of anti-inflammatory