DIPHENYLAMINE DERIVATIVES: APPLICATION, METHOD OF SYNTHESIS AND FRAMACEUTICAL COMPOSITIONS

摘要

1. The compound of formula (I) or its salt, prodrug or solvate: where Ph is phenyl; n is 2, 3 or 4; R is selected from the group consisting of hydrogen and C 1-6 alkyl; R is a radical of the formula - [[CH (R) ] -R], where m is 1; R, where provided, is selected from the group consisting of hydrogen, phenyl and C-C1-6 alkyl; R is selected from the group consisting of radicals: unsubstituted heteroaryl, substituted heteroaryl and substituted aryl, wherein these substituents are selected from a group consisting of C 1-6 alkyl, C 1-6 arylalkyl, phenyl, 5- or 6-membered heteroaryl, F, Cl, Br, I, trifluoromethyl, cyano, —N (R) (R), —OR, —SR, or —C ( O) R; where R, R, R, R and R are independently selected from a hydrogen atom, C 1-6 alkyl, phenyl and trifluoromethyl; or if R and / or R are different from a hydrogen atom, then R may also mean unsubstituted phenyl; or R and R, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl group in which the indicated substituents are as defined above, provided that: 2 - [(4,4-diphenylbut-3-enylamino) methyl] phenol 3 - [(4,4-diphenylbut-3-enylamino) methyl] phenol, 5 - [(4,4-diphenylbut-3-enylamino) methyl] -2-methoxyphenol, 4 - [(4,4-diphenylbut -3-enylamino) methyl] -2,6-difluorophenol, benzyl- (5,5-diphenylpent-4-enyl) ethylamine, 6-chloro-9- (4,4-diphenylbut-3-enyl) -9H-purine , 9- (4,4-diphenylbut-3-enyl) -9H-purin-6-ylamine, and 5- (4,4-diphenylbut-3-enyl) -4,5,6,7-tetrahydroisoxazolo [4,5 -c] pyridin-3-o l are not included in formula (I) .2. The compound according to claim 1, where each of these substituents is selected from the group consisting of C 1-6 alkyl, C 1-6 arylalkyl, phenyl, 5- or 6-membered heteroaryl, F, Br, I, trifluoromethyl, cyano, —N (R) ( R), —OR, —SR or —C (O) R; where R, R, R and R are independently selected from a hydrogen atom, C-C1-6 alkyl, phenyl and trifluoromethyl, and R is selected from the group consisting of C-C1-6 alkyl, phenyl and trifluoromethyl, provided that -N (R) (R) is not