Microcapsule preparation based on chitosan alginate-acyl derivatives, its preparation and use

摘要

1. A microcapsule preparation based on alginate-acyl derivatives of chitosan obtained by mixing microcapsules from alginate-acyl derivatives of chitosan with an aqueous solution, where the structure of the microcapsule consists of two parts: the membrane of the microcapsule and the inner core; the microcapsule membrane is a polyelectrolyte composite hydrogel membrane formed by chitosan, alginates and acyl derivatives of chitosan, and the inner core is an alginate liquid or hydrogel medium containing cells. 2. The microcapsule preparation according to claim 1, characterized in that the microcapsules in the preparation are spherical microcapsules with a particle size of from 10 to 2000 microns; the thickness of the membrane is from 0.1 to 100 μm, and the molecular weight of the alginate forming the membrane is from 10 kDa to 2000 kDa; chitosan material has a deacetylation degree of from 70 to 98% and a molecular weight of 1 kDa to 500 kDa; the molecular weight of the acyl derivatives of chitosan is from 1 kDa to 800 kDa; the mass ratio of chitosan, alginate and acyl derivatives of chitosan is from 0: 1: 0.1 to 10: 1: 10; and the concentration of alginate in the core is from 0.1 to 50 g / l. 3. The microcapsule preparation according to claim 1 or 2, characterized in that in the preparation the acyl derivatives of chitosan in the microcapsule are N-acyl chitosan with the monomeric structure shown below: where R is formyl, acetyl, propionyl, butyryl, valeryl or caproyl; the degree of substitution of acyl derivatives is from 10 to 60%; the molecular weight of the chitosan frame material is from 1 to 400 kDa; and the degree of deacetylation is