Microcapsule preparation of alginate-chitosan acyl derivatives, preparation and application thereof

摘要

Disclosed is a biomicrocapsule preparation of alginate-chitosan acyl derivatives, comprising microcapsules of alginate-chitosan acyl derivatives or formed by mixing microcapsules of alginate-chitosan acyl derivatives with aqueous solution, wherein: the biomicrocapsule structure consists of two parts, a microcapsule membrane and an inner core; the microcapsule membrane is a polyelectrolyte composite hydrogel membrane formed by chitosan, alginates and chitosan acyl derivatives, and the inner core is an alginate liquid or hydrogel environment containing ex vivo or in vitro cells, wherein the chitosan acyl derivatives in the microcapsule are N-acyl chitosan, with a monomer structure as disclosed in the specification. Also disclosed are methods of preparing said biomicrocapsule and its use in cell encapsulation.