INTRODUCTION MODE FOR NITROCATCHERS

摘要

1. The compound of formula (I) where R and R are the same or different and represent hydrogen atoms, groups hydrolyzable under physiological conditions, or possibly substituted alkanoyl or aroyl; X represents a methylene group; Y represents O, S or NH; n is 0, 1, 2 or 3; m is 0 or 1; R denotes a pyridine N-oxide group of the formula A, B or C, which is attached as indicated by the "open" bond: where R, R, F and R are identical or different and are hydrogen, alkyl, thioalkyl, alkoxy, aryloxy, thioaryl, alkanoyl, aroyl, aryl, amino, alkylamino, dialkylamino, cycloalkylamino, heterocycloalkylamino, alkylsulfonyl, arylsulfonyl, halogen, haloalkyl, trifluoromethyl, cyano, nitro or heteroaryl; or two or more than two of R, R, R and R, taken together, are aliphatic or heteroaliphatic rings or aromatic or heteroaromatic rings; the term “alkyl”, including its variant “alk—” in terms such as “alkoxy”, “alkanoyl”, means carbon residues, straight or branched, containing from one to six carbon atoms; the term “aryl” means a phenyl or naphthyl group; the term “heterocycloalkyl” means a four-membered to eight-membered ring, optionally including at least one oxygen, sulfur or nitrogen atom; the term “heteroaryl” means a five-membered or six-membered ring comprising at least one sulfur, oxygen or nitrogen atom; the term “halogen” means fluoro, chloro, bromo or iodo; and if R, R, R, and R are alkyl or aryl, they are optionally substituted with one or more hydroxy, alkoxy, or halogen groups; or its pharmaceutically acceptable salt, ester, carbamate or fo