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TARGETING THE BLOOD COAGING FACTORS TO THE TLT-1 RECEPTOR ON THE SURFACE OF ACTIVATED Platelets
TARGETING THE BLOOD COAGING FACTORS TO THE TLT-1 RECEPTOR ON THE SURFACE OF ACTIVATED Platelets
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机译：将血小板凝集因子定位于活性血小板表面上的TLT-1受体
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摘要
1. A coagulating protein containing (i) at least one coagulation factor covalently attached to (ii) a monoclonal antibody or fragment thereof, which is capable of specifically binding to (iii) TLT-1 and / or its fragment or variant. The coagulating protein according to claim 1, wherein component (i) is a serine protease or its derivative. The coagulating protein according to claim 2, wherein component (i) is a factor FVII.4 polypeptide. The procoagulating protein according to claim 2, wherein component (i) is a FIX.5 factor polypeptide. The coagulating protein according to claim 1, wherein component (ii) is a Fab.6 fragment. The coagulating protein according to claim 1, wherein the epitope for component (ii) contains one or more residues selected from the group consisting of V17, Q18, C19, H20, Y21, R22, L23, Q24, D25, V26, K27, A28 , L63, G64, G65, G66, L67, L68, G89, A90, R91, G92, P93, Q94, I95 and L96 from the sequence of SEQ ID NO: 5.7. The coagulating protein according to claim 1, wherein the epitope for component (ii) contains one or more residues selected from the group consisting of L36, P37, E38, G39, C40, Q41, P42, L43, V44, S45, S46, A47 , V73, T74, L75, Q76, E77, E78, D79, A80, G81, E82, Y83, G84, C85, M86, R91, G92, P93, Q94, I95, L96, H97, R98, V99, S100 and L101 from the sequence of SEQ ID NO: 5.8. The coagulating protein according to claim 1, wherein the epitope for component (ii) contains one or more residues selected from the group consisting of V17, Q18, C19, H20, Y21, R22, L23, Q24, D25, V26, K27, A28 , R91, G92, P93, Q94, I95, L96, H97, R98, V99, S100 and L101 from the sequence of SEQ ID NO: 5.9. The coagulating protein according to claim 1, wherein the epitope for component (ii) contains one or more residues selected from the group consisting of K118, I119, G120, S121, L122, A123, E124, N125 and A126, F127 from the sequence SEQ ID NO: 6.10. The coagulating protein according to claim 1, wherein the epitope for component (ii) contains one il�
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机译：1.一种凝结蛋白，其包含（i）与（ii）单克隆抗体或其片段共价连接的至少一种凝结因子，其能够特异性结合（iii）TLT-1和/或其片段或变体。 2.根据权利要求1所述的凝血蛋白质，其中，成分（i）是丝氨酸蛋白酶或其衍生物。 3.根据权利要求2所述的凝血蛋白，其中，成分（i）是因子VII.4多肽。 3.根据权利要求2的促凝血蛋白，其中组分（i）是FIX.5因子多肽。 2.根据权利要求1的凝血蛋白，其中组分（ii）是Fab.6片段。 2.根据权利要求1所述的凝血蛋白质，其中，成分（ii）的表位含有选自V17，Q18，C19，H20，Y21，R22，L23，Q24，D25，V26，K27，A28中的一个以上残基。 SEQ ID NO：5.7的序列中的L63，G64，G65，G66，L67，L68，G89，A90，R91，G92，P93，Q94，I95和L96。 2.根据权利要求1所述的凝血蛋白质，其中，成分（ii）的表位含有选自L36，P37，E38，G39，C40，Q41，P42，L43，V44，S45，S46，A47中的1个以上的残基。 ，V73，T74，L75，Q76，E77，E78，D79，A80，G81，E82，Y83，G84，C85，M86，R91，G92，P93，Q94，I95，L96，H97，R98，V99，S100和L101 SEQ ID NO：5.8的序列。 2.根据权利要求1所述的凝血蛋白质，其中，成分（ii）的表位含有选自V17，Q18，C19，H20，Y21，R22，L23，Q24，D25，V26，K27，A28中的一个以上残基。 SEQ ID NO：5.9的序列中的R91，G92，P93，Q94，I95，L96，H97，R98，V99，S100和L101。 2.根据权利要求1所述的凝血蛋白，其中，成分（ii）的表位含有选自序列SEQ ID NO：1的一个或多个残基，所述残基选自K118，I119，G120，S121，L122，A123，E124，N125和A126，F127。身份证号码：6.10。 2.根据权利要求1的凝血蛋白，其中组分（ii）的表位包含一个il。
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