METHODS OF TARGETED TREATMENT OF FACE-TIMO LOBAR DEGENERATION

摘要

1. A method of treating frontotemporal dementia (LVD) or frontotemporal lobar degeneration (LVLD), comprising administering to the patient, if necessary, an effective amount of a composition containing a compound of formula (IV): or a pharmaceutically acceptable salt thereof, wherein R is selected from the group, including H, -OH, halogen, -CN, -C-C1-6alkyl, -C-Alkoxyl, -OC-Alkyl-OC-Alkyl, -CF, -OCF, -NO, -C-Alkyl-S (O) R, -NH, -NRR, -C-C1-6alkyl-NRR, and -N (C-C1-6alkyl); xa and xb are numbers, each of which is independently selected from 0, 1 and 2; and R and R are independently selected from the group consisting of H, halogen, —CN, —CF, —OCF, —C-C1-6alkyl, —C-Alkoxyl, —OC-Alkyl-OR, —OR, —C-Alkyl-S (O) - R, -C-C1-6alkyl-C (O) -R, -C-C1-6alkyl-C (O) NRR, -C-C1-6alkyl-NRC (O) -R, -C-C1-6alkyl-S (O) NRR, -C -Calkyl-NRS (O) -R, -C-C1-6alkyl-OC (O) NRR, -C-C1-6alkyl-NRC (O) OR, -C-C1-6alkyl-NRC (O) NRR, -C-C1-6alkyl ( O) OR, -C-C1-6alkyl-OC (O) -R, -C-C1-6alkyl-aryl, -C-C1-6alkyl-heteroaryl, -C-C1-6alkyl-cycloalkyl, -C-C1-6alkyl-heterocyclyl, -NH, -NRR, -C-C1-6alkyl-NRR, -OC-C1-6alkyl-NRR, -NR-C-C1-6alkyl-NRR, and -O-heterocyclyl-R, where each alkyl and heteroalkyl is optionally substituted with one or three substituents independently selected from the group consisting of F, - OH and oxo and where each aryl, heteroaryl, cycloalkyl and heterocyclyl are optionally substituted with one or two substituents independently selected from the group consisting of halogen, —CN, —C-C1-6alkyl, —C-Alkoxyl, —OC-Alkyl-OC-Alkyl, —CF, —OCF, -NO, -C-C1-6alkyl-S (O) R, -NH, -NRR, -C-C1-6alkyl-NRR, and -N (C-C1-6alkyl); R and R are independently selected from the group consisting of H, -C-C1-6alkyl, -C -Calkyl-OC-C1-6alkyl, -C-C1-6alkyl-C-Cycloalkyl, where each alkyl and cycloalkyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, -OH, amino, -CN or -C-C1-6alkyl; or R R, together with the atom N, to which they are attached optionally form a 3-10 membered heterocyclic to