LACTOBACILLUS PARACASEI NCC2461 (ST11) FOR PERINATAL PERIOD USE IN WOMEN TO REDUCE AND PREVENT ALLERGIC PHENOMENA IN CHILDREN

摘要

1. Lactobacillus paracasei NCC 2461 (ST11) for use by administering to pregnant women and, if necessary, to them after childbirth during breastfeeding and to children born to these mothers to weaken or prevent the development of allergic immune reactions in these children. Lactobacillus paracasei NCC 2461 (ST11) according to claim 1, in which for these children there is a risk of developing atopic diseases. Lactobacillus paracasei NCC 2461 (ST11) according to claim 1 or 2, in which allergic immune reactions occur in response to allergens contained in food and / or air, in particular to allergens of birch pollen Bet v 1 and Bet v 2 and / or food allergens that cross-react with tree allergens, in particular with birch pollen allergens Bet v 1 and Bet v 2.4. Lactobacillus paracasei NCC 2461 (ST11) according to claim 1 or 2, wherein said allergic immune responses may be a secondary immune response specific for an allergen or an immune response not specific for an allergen. Lactobacillus paracasei NCC 2461 (ST11) according to claim 1 or 2, wherein the attenuation of said allergic immune reactions in said children is (i) a decrease in the production of interleukins 4 and 5 (IL-4, IL-5) in the case of a secondary immune response specific in relation to the allergen, and / or (ii) a decrease in the production of interleukin 5 (IL-5) in the case of an immune response that is not specific for the allergen, and these immune responses are weakened compared to the children of mothers not receiving ST11.6. Lactobacillus paracasei NCC 2461 (ST11) according to claim 1 or 2, wherein ST11 is administered to expectant mothers for at least two weeks before delivery and after delivery to their children directly or through mother's milk for at least 2 months, preferably up to six months n