EXPANDABLE DEVICES COATED FROM A PACLITAXEL COMPOSITION

摘要

1. A medical device, comprising: an expandable element having a first diameter for insertion into the vessel and a second diameter to ensure contact with the walls of the vessel; non-aqueous composition of paclitaxel, including its synthetic and semi-synthetic analogues, applied and dried on at least a portion of the surface of the expandable element, the non-aqueous composition containing paclitaxel in a therapeutic dose in the range of up to ten micrograms per square millimeter of the surface area of the expandable element, an antioxidant in an amount of up to 5% by weight of the amount of paclitaxel, a film-forming agent in a pharmaceutically acceptable range from 0.05% to about 20% by weight and essentially does not contain volatile a non-aqueous rastvoritelya.2. The medical device of claim 1, wherein the expandable member is a balloon. 3. The medical device according to claim 2, further comprising a stent placed on top of the balloon. 4. The medical device of claim 1, wherein the antioxidant is butylated hydroxyltoluene. A medical device according to claim 1, wherein the film-forming agent comprises polyvinylpyrrolidone. The non-aqueous composition of paclitaxel, including its synthetic and semi-synthetic analogues, containing paclitaxel in a dose in the therapeutic range, an antioxidant in an amount up to 5% by weight of the amount of paclitaxel and a film-forming agent in a pharmaceutically acceptable range from 0.05% to about 20% by weight on the amount of paclitaxel. 7. The non-aqueous composition of paclitaxel according to claim 6, wherein the antioxidant is butylated hydroxyltoluene. The non-aqueous composition of paclitaxel according to claim 6, in