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METHOD (VARIANTS) AND KIT FOR DIAGNOSIS OF INFECTION URINARY TRACT, method of treatment and detection of predisposition to infection urinary tract

机译:诊断感染性尿道的方法(试剂盒),治疗方法和感染尿路易感性的检测

摘要

1. A method of detecting urinary tract infection in a patient, comprising: a) providing a sample from the patient; and b) detecting in said sample BCL6.2 CD1d receptor and biomarker expression. A method according to Claim. 1, comprising detecting the presence of mRNA for the receptor and CD1d BCL6.3. The method of claim. 2, comprising reacting said mRNA for the receptor and CD1d BCL6 a nucleic acid probe complementary to said mRNA for the receptor and CD1d BCL6.4. A method according to Claim. 1, comprising detecting the presence of receptor polypeptides and CD1d BCL6.5. A method according to claim. 4, comprising reacting said CD1d receptor and BCL6 polypeptides with an antibody specific to said polypeptide and BCL6 CD1d receptor and detecting the binding of said antibody to said polypeptide receptor and CD1d BCL6.6. A method according to Claim. 1, in which the test is chelovek.7. The method of claim. 1, wherein the sample comprises urine, blood, and / or cell or tissue puzyrya.8 bladder. A method for treating urinary tract infections, comprising: a) providing a sample of the test; b) detecting expression of CD1d receptor and BCL6 in said sample; c) on the basis of said expression BCL6 CD1d receptor and suppression of inflammation with monoclonal antibodies and / or soluble receptors and / or anti-protease inhibitors, respectively, or a polypeptide BCL6.9 receptor and CD1d gene. Set to describe infections of the urinary tract in a test comprising: a) a reagent possessing the ability to specifically detect the presence or absence of expression of BCL6 and CD1d receptor; and b) instructions for using said kit to describe infections of the urinary tract in that ispytuemom.10. The kit of claim. 9, in which the decree
机译:1.一种检测患者尿路感染的方法,其包括:a)从所述患者提供样品; b)在所述样品中检测BCL6.2CD1d受体和生物标志物的表达。根据权利要求1的方法。 1,包括检测受体和CD1d BCL6.3的mRNA的存在。权利要求的方法。如图2所示,其包括使所述受体mRNA和CD1d BCL6反应,该核酸探针与所述受体mRNA和CD1d BCL6.4互补。根据权利要求1的方法。 1,包括检测受体多肽和CD1d BCL6.5的存在。根据权利要求1的方法。 4,包括使所述CD1d受体和BCL6多肽与对所述多肽和BCL6CD1d受体具有特异性的抗体反应,并检测所述抗体与所述多肽受体和CD1dBCL6.6的结合。根据权利要求1的方法。 1,其中测试为chelovek.7。权利要求的方法。 1,其中样品包含尿液,血液和/或细胞或组织的puzyrya.8膀胱。一种治疗尿路感染的方法,包括:a)提供测试样品; b)检测所述样品中CD1d受体和BCL6的表达; c)基于所述表达BCL6CD1d受体并分别用单克隆抗体和/或可溶性受体和/或抗蛋白酶抑制剂或多肽BCL6.9受体和CD1d基因抑制炎症。在测试中描述尿路感染的方法,包括:a)具有特异性检测BCL6和CD1d受体表达存在或不存在的能力的试剂; b)使用所述试剂盒描述该脓毒症中尿路感染的说明。10。索赔套件。 9,其中法令

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