THERAPY OF TUMOURS WITH APPLICATION OF ANTIBODY TO VASCULAR ENDOTHELIAL GROWTH FACTOR AND ANTIBODIES TO HUMAN EPITHELIAL GROWTH FACTOR RECEPTOR TYPE 2

摘要

FIELD: medicine.;SUBSTANCE: group of inventions relates to medicine and deals with application of antibody to HER2 and/or antibody to VEGF for preparation of medication intended for reduction of metastases in treatment of breast cancer, characterised by super-expression of HER2 receptor protein in patient, unsusceptible to preceding therapy with application of antibody to VEGF, in which treatment includes introduction to patient of therapeutically effective amount of antibody to HER2 and antibody to VEGF, with antibody to VEGF representing bevacizumab, and antibody to HER2 representing trastuzumab. Group of inventions also deals with application of antibody to HER2 for reduction of metastases in method of breast cancer treatment and application of antibodies to VEGF for reduction of methastases in method of breast cancer treatment.;EFFECT: combination of bevacizumab and trastuzumab makes it possible to achieve prevention of metastases formation.;12 cl, 1 ex, 2 dwg, 4 tbl