DIAGNOSTIC TECHNIQUE FOR OXIDATIVE STRESS IN CHILDREN EXPOSED TO NICKEL FROM EXTERNAL ENVIRONMENT

摘要

FIELD: medicine.;SUBSTANCE: invention describes the diagnostic technique for oxidative stress in children exposed to nickel from the external environment and involves measuring nickel in blood samples and determining the laboratory values: in blood serum - lipid hydroperoxide, in urine - 8-hydroxy-2-deoxyguanosine; that is follows by a correlation analysis of the above laboratory values and blood nickel, if establishing the significant dependencies: high blood nickel more than 0.083 mg/dm³ and blood serum lipid hydroperoxide increased as compared to the reference and urine 8-hydroxy-2-deoxyguanosine increased as compared to the reference enables diagnosing the oxidative stress in the body at the level of cell DNA and membrane.;EFFECT: invention provides high diagnostic accuracy for the oxidative stress at the early stage in the exposure to nickel from the external environment by the complex use with interpreting the results along with the laboratory values describing the oxidative damages of cell DNA and membrane, as well as the values of blood chemical contaminant - blood nickel.;2 tbl, 2 dwg, 1 ex