POLYMORPH OF (4-HYDROXYCARBAMOYLPHENYL)CARBAMINIC ACID (6-DIETHYLAMINOMETHYL-2-NAPHTHALENYL)METHYL ETHER HYDROCHLORIDE

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention relates to a novel crystalline form of a compound of formula , which possesses higher solubility in water and storage stability. The novel crystalline form II of formula (A) compound is characterised by the presence of a profile of powder X-ray diffraction with the following peaks ±0.20° (2 theta): 5.10; 10.07; 14.90; 15.15; 15.67; 17.24; 17.84; 18.51; 19.23; 20.25; 20.37; 22.01; 22.63; 23.12; 24.76; 25.40; 27.78; 28.97; 31.02. The invention also relates to a method of obtaining the formula (A) compound in the crystalline form II and solid pharmaceutical compositions, containing the said crystalline form.;EFFECT: obtaining the novel n crystalline form of the compound.;11 cl, 2 tbl, 5 dwg, 5 ex