METHOD FOR PHARMACOLOGICAL STIMULATION OF NEOANGIOGENESIS IN TREATING ACUTE EXPERIMENTAL LIMB ISCHEMIA

摘要

FIELD: medicine.;SUBSTANCE: acute limb ischemia is simulated in Wistar male rats by excising a segment of great vessels containing a femoral artery, a popliteal artery and initial segments of shin arteries. The operation is performed under chloral hydrate anaesthesia in a dose of 250-300 mg/kg. Through 5 days immediately following the surgery, Actovegin is introduced intraperitoneally in a dose of 50 mcg/kg daily once a day.;EFFECT: method provides stimulating neoangiogenesis and activation of developing collateral blood flow in the ischemic limb and thereby improvement of the arterial blood inflow from the proximal portions of the limb into distal ones.;1 ex, 1 tbl