N-(3-CYANO-4,5,6,7-TETRAHYDROBENZObTHIEN-2-YL)AMIDE 1-(4-BROMOBENZOYL)-5-HYDROXY-3-(4-METHYLPHENYL)-4,5-DIHYDRO-1H-PYRAZOLE-5-CARBOXYLIC ACID, HAVING ANALGESIC ACTIVITY

摘要

FIELD: chemistry.SUBSTANCE: invention relates to novel biologically active substances of the class of N-acyl-derivatives of 2-aminothiophene, specifically to N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)amide of 1-(4-bromobenzoyl)-5-hydroxy-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid having the formula given below. The disclosed compound is obtained by reacting 2-[5-(4-methylphenyl)-3-oxofuran-2(3H)-ylideneamino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile with 4-bromobenzoylhydrazine in anhydrous toluene at 60°C and stirring for 2 hours, followed by separation of the end product using existing methods.EFFECT: obtaining a compound with high output, having marked analgesic activity and low toxicity.1 tbl