METHOD OF PRODUCING ALKYL 2-SUBSTITUTED 6H-BENZOTHIENO2,3,4-ij-2,7-NAPHTHYRIDINE-5-CARBOXYLATES

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a method of producing alkyl 2-substituted 6H-benzothieno[2,3,4-ij]-2,7-naphthyridine-5-carboxylates of general formula 1 , where 1a Ar=Ph, R=H, R′=Et; 1b Ar=4-CH₃O-C₆H₄, R=CH₃, R'=Et; 1c Ar=4-CH₃-C₆H₄, R=CH₃, R'=Am; 1d Ar=4-CH₃-C₆H₄, R=CH₃O, R'=Et; 1e Ar=Ph, R=H, R'=Am, which can be used as potentially biologically active substances and semi-products for synthesis of novel heterocyclic systems. The method of producing alkyl 2-substituted 6H-benzothieno[2,3,4-ij]-2,7-naphthyridine-5-carboxylates of general formula I includes forming a heterocyclic system of 6H-benzothieno[2,3,4-ij]-2,7-naphthyridine as a result of thermal decomposition of the azido group of alkyl 3-azidothieno[2,3-b]pyridine-2-carboxylates and intramolecular cyclisation of the formed nitrene; the reaction is carried out while boiling said compounds in chlorobenzene for 30-60 minutes.;EFFECT: high output.;3 tbl, 6 ex