Method for the quantitative characterization of substances with regard to their binding properties to amyloid β (Aβ) conformers

摘要

The invention relates to a method for the quantitative characterization of substances with respect to their binding properties to amyloid β (Aβ) conformers comprising the steps of: - a sample comprising different Aβ conformers is fractionated, - Biotinylated Aβ conformer of the desired fraction is obtained The binding behavior of an aggregate quality control probe to the desired Aβ conformer is derived from the measurement signal by determining the kinetic and / or thermodynamic parameters. An apparatus for carrying out the method is disclosed.