Improved apparatus and method for reactions between a solid and a liquid phase

摘要

The present invention relates to a device for contacting an immobilized reactant with at least one liquid comprising a trough with a bottom from which protrudes at least one elevation with an upper side into the interior of the trough, wherein the at least one elevation has a channel which Bottom of the tub to the upper side of the survey, preferably perpendicular to the bottom of the tub and opens on the upper side of the survey in at least one outlet opening, wherein the channel is fed via a feed element by means of a pumping device from at least one liquid reservoir, the at least one liquid a holding device configured to releasably hold at least one slide, preferably a plurality of slides, having at least one adhesion surface with the immobilized reactant such that the adhesion surface faces the interior of the tub; and that the upper side of the bump and the adhesion surface are positioned relative to each other so that liquid emerging from the exit orifice is in contact with the immobilized reagent, the device optionally comprising a slide introduced into the support device and a method for contacting an immobilized reactant with at least one liquid, comprising the steps of a) immobilizing the reaction partner on the adhesion surface of at least one slide suitable for insertion into the fixture of the device of the invention, b) if the previous steps have been performed outside the device of the invention: placing the slide in the fixture Holding device of the device according to the invention, preferably via a transport device in the device according to the invention, c) introducing the at least one liquid via the Zuführeleme nt in the direction of the outlet opening until the at least one liquid is in contact with the immobilized reactant.