INTRAOPERATIVE TRIFUNCTIONAL ANTIBODY APPLICATION FOR PROPHYLATIC INTRAPERITONAL TUMOUR CELL DISSEMINATION

摘要

Use of trifunctional, bispecific and/or trispecific antibodies for the production of a composition for the destruction of tumor cells, which are intraperitoneally disseminated by surgical intervention and for the prophylaxis of tumor cells causing tumor recurrence, where the tumor cells are intraperitoneally disseminated by surgical intervention, is claimed, where the antibodies exhibit the following characteristics: bind to T-cells; bind to at least a tumor associated antigen; and bind through its fragment crystallizable (Fc)-portion at Fc-receptor positive cells. Use of trifunctional, bispecific and/or trispecific antibodies for the production of a composition for the destruction of tumor cells, which are intraperitoneally disseminated by surgical intervention and for the prophylaxis of tumor cells causing tumor recurrence, where the tumor cells are intraperitoneally disseminated by surgical intervention, is claimed, where, the antibody is administered intraoperatively, preferably directly locally into the abdominal cavity in a quantity of 1-400 mu g and the antibodies exhibit the following characteristics: bind to T-cells; bind to at least a tumor associated antigen, which expressed on intraperitoneally occurring tumor cells; and bind through its fragment crystallizable (Fc)-portion (in bispecific antibodies) or through a third specificity (in trispecific antibodies) at Fc-receptor positive cells. ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.