ION POPULATION CONTROL IN A MASS SPECTROMETER HAVING MASS-SELECTIVE TRANSFER OPTICS

摘要

Methods are provided for operating a mass spectrometer having at least one component through which ion transmission is dependent on ionic mass-to-charge-ratio, the methods characterized by: (a) injecting a first sample of ions having a first range of mass to-charge ratios into an ion accumulator of the mass spectrometer (b) acquiring a full-scan mass spectrum of the first sample of ions; (c) selecting, based on the full scan mass spectrum, ion species having a second range of mass-to-charge ratios, the second range different than the first range; (d) calculating a second injection time, (e) injecting a second sample of ions having the selected ion species into the ion accumulator for the second injection time under the second operating conditions; and (f) acquiring a mass spectrum of ions derived from the selected ion species in the mass spectrometer.