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ENHANCEMENT OF ORAL BIOAVAILABILITY OF NON-EMULSIFIED FORMULATION OF CEFDITOREN PIVOXIL WITH LECITHIN
ENHANCEMENT OF ORAL BIOAVAILABILITY OF NON-EMULSIFIED FORMULATION OF CEFDITOREN PIVOXIL WITH LECITHIN
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机译:卵磷脂与头孢呋辛酯联用未乳化制剂的口服生物利用度的提高
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摘要
A method for enhancing the oral bioavailability of a prodrug ester by formulating the ester as non-emulsified formulation with lecithin; as well as a pharmaceutical composition of at least one antibiotic and lecithin in a non-emulsified formulation; a method of treating infections with the non-emulsified formulation, and a method for preparing tablets by direct compression of blends of drugs with lecithin are disclosed. Non-emulsified formulations include solids, tablets, capsules, lozenges, suspensions, elixirs and solutions, and exclude emulsions, liposomes, lipid matrix systems and micro-emulsions. A suitable prodrug ester is a cephalosporin ss-lactam antibiotic such as cefditoren pivoxil, and a suitable non-emulsified formulation is a solid formulation.
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