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METHODS AND COMPOSITIONS FOR NANOPARTICLE-MEDIATED CANCER CELL-TARGETED DELIVERY
METHODS AND COMPOSITIONS FOR NANOPARTICLE-MEDIATED CANCER CELL-TARGETED DELIVERY
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机译:纳米粒子介导的癌细胞靶向递送的方法和成分
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摘要
The present invention provides methods and compositions to selectively and directly deliver nanoparticles carrying an active agent to tumor cells. The active agent is internalized by the tumor cells, producing an anti-tumor effect for therapeutic applications and/or depositing a detectable marker for diagnostic applications. The present invention further provides a p53 chimera that circumvents the dominant negative activity of mutant p53 as a therapeutic in the treatment of cancer and reduction of mor size.
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