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SPATIAL AND CELLULAR MAPPING OF BIOMOLECULES IN SITU BY HIGH-THROUGHPUT SEQUENCING
SPATIAL AND CELLULAR MAPPING OF BIOMOLECULES IN SITU BY HIGH-THROUGHPUT SEQUENCING
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机译:高通量序列在原位生物分子的空间和细胞映射
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摘要
The present invention relates to molecular microscopy or volumetric imaging by proximal unique molecular identifiers (“UID”) reaction (“VIPUR”) microscopy methods to record the cellular co-localization and/or spatial distributions of arbitrary nucleic acid sequences, or other biomolecules tagged with nucleic sequences. The method involves one or both of two DNA sequence-components such as an α-UID, which may identify the targeted sequences-of-interest themselves and/or spatial beacons relative to which their distances are measured, and a −β-UID, which labels α-UID association events.
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