COCRYSTAL OF PIPERACILLIN SODIUM AND SULBACTAM SODIUM AND PREPARATION METHOD THEREOF, AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF

摘要

Provided in the present invention are a cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing the same and uses thereof in treating infections caused by drug-resistant bacteria, such as a "super bacterium" producing NDM-1 and the like. The cocrystal of piperacillin sodium and sulbactam sodium contains diffraction angles of 14.24°, 16.58°, 16.79°, 17.77°, 19.20°, 20.21°, 20.39°, 23.06°, 27.86° and 32.16° represented by 2¸ in an X-ray powder diffraction analysis spectrum.