PHARMACOLOGICAL TREATMENT OF COGNITIVE IMPAIRMENT USING GABAA RECEPTOR ANTAGONISTS

摘要

Methods for treating an individual to improve cognitive function are provided. In the subject methods, an effective amount of a noncompetitive GABA_A ionophore blocker (e.g.pentylenetetrazole, picrotoxin or bilobalide) is administered to the individual, resulting in an improvement in cognitive function of the host. The subject methods find use in a variety of different applications, like Down Syndrome, Phenylketonuria, Fragile-X-Syndrome, Neurofibromatosis-1, Maple Syrup Urine Disease or Rett Syndrome.