CYCLIC OCTAPEPTIDE, RADIOPHARMACEUTICAL AGENT BASED THEREON AND METHOD FOR USING A RADIOPHARMACEUTICAL AGENT TO PRODUCE MEDICINAL (PHARMACEUTICAL) AGENTS FOR THE TREATMENT OF NEOPLASMS WHICH EXPRESS SOMATOSTATIN RECEPTORS

摘要

The invention refers to cyclic octapeptides being analogues of somatistatin, which can be applied for obtaining of various pharmaceutical means applied upon diagnostics or treatment, i.e. refers to the area of chemistry and medicine. Octapeptide meets the general claims (I):and it is intended for obtaining of radiopharmaceutical means with radionuclides ¹¹¹In, ⁹⁰Y, ¹⁷⁷Lu.;Cyclic octapeptide contains terminal amino acid lysine (Lys) capable of covalent attachment of the chelating agent and thus having the following structure (Ia) and (Ib)X = chelating agent;Cyclic octapeptide of the general claims (I) is a biologically active molecule, and being a somatostatin analogue, cyclic octapeptide under invention is applied for obtaining of radiopharmaceutical means with radionuclides ¹¹¹In, ⁹⁰Y, ¹⁷⁷Lu;The obtained radiopharmaceutical means can be applied for obtaining of the medical preparations and treatment of neoplasms (tumors) expressing somatistain receptors.;Long with that, compounds of the claim (I) with radionuclides ¹¹¹In, ⁹⁰Y, ¹⁷⁷Lu are obtained with the use of the chelating agents. These octapeptides under the invention inhibit release of such hormones as growth hormone, lactogenic hormone, decrease secretion of insulin, glucagon, thrombotonin; can be applied for the treatment of acromegaly, diabetes, acute pancreatitis.;3 independent claims, 1 dependent claim, 2 tables, 6 examples, 1 figure.