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Compositions and methods for inhibiting 'stimulating factor of interferon gene' dependent signaling
Compositions and methods for inhibiting 'stimulating factor of interferon gene' dependent signaling
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机译:抑制“干扰素基因的刺激因子”依赖性信号传导的组合物和方法
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摘要
The present invention provides a cyclic dinucleotide (CDN) compound that suppresses signaling at a recently discovered cytoplasmic receptor known as STING (interferon gene stimulator). In particular, the CDN of the invention is provided in the form of a composition comprising one or more cyclic purine dinucleotides that suppress STING-dependent TBK1 activation and the resulting production of type I interferons. [Selection] Figure 1
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