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Compositions and methods for inhibiting 'stimulating factor of interferon gene' dependent signaling
Compositions and methods for inhibiting 'stimulating factor of interferon gene' dependent signaling
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机译:抑制“干扰素基因的刺激因子”依赖性信号传导的组合物和方法
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摘要
The present invention provides cyclic-di-nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit STING-dependent TBK1 activation and the resulting production of type I interferon.
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