Bifunctional fusion protein with inhibition of revascularization and activation of adaptive immune response in tumor microenvironment and gene and use thereof

摘要

The present invention discloses a bifunctional fusion protein having a Tumstatin active fragment and a CD137L extracellular region. The protein suppresses human umbilical vein endothelial cell proliferation and co-stimulates T cell proliferation activity, and can be used for the production of angiogenesis inhibitors, various tumor-related diseases, bioimmunomodulatory drugs and the like.