MONOCLONAL ANTIBODY THAT RECOGNIZES AMPA TYPE GLUTAMIC ACID RECEPTOR SUBUNIT AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To develop a novel technique of providing an anti-GluA1 antibody that can destruct the function of GluA1 specifically with light by CALI (chromophore assisted light inactivation) and inducing the erasure of memory.SOLUTION: The present invention provides a monoclonal antibody for an extracellular domain of GluA1, the monoclonal antibody capable of suppressing or destructing the function of an AMPA type glutamic acid receptor specifically with light irradiation by CALI, and also provides a fragment thereof having the stated function.SELECTED DRAWING: None