COMPOSITION THAT RECOGNIZES ANTIBODY DERIVED FROM IMMUNE PERIPHERAL NEUROPATHY, AND USE OF THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a ganglioside sugar-chain immobilized fluorescent nanoparticle that allows quick and simple detection of a ganglioside-binding autoantibody present in serum of a patient who has immune peripheral neuropathy, such as Guillain-Barre syndrome, and a method of detecting the ganglioside-binding autoantibody.;SOLUTION: A sugar-chain ligand complex is produced by causing a sugar chain part of a ganglioside GM1 or the like to bind a proprietary fluorescent linker, the sugar chain part being obtained through chemical synthesis, by isolating from a natural product, or as an available product, and the sugar-chain ligand complex is immobilized to a metallic particle that consists of immobilized cadmium and tellurium, and that emits a fluorescence, to produce a ganglioside sugar-chain immobilized fluorescent nanoparticle. Then, the ganglioside sugar-chain immobilized fluorescent nanoparticle and a serum of a patient who has peripheral neuropathy are mixed, left standing for one to three hours, and centrifuged to form an aggregate that emits a fluorescence specifically with a serum of a patient who has Guillain-Barre syndrome. The aggregate is subject to visual observation to perform a diagnosis of Guillain-Barre syndrome quickly and simply.;SELECTED DRAWING: Figure 12;COPYRIGHT: (C)2016,JPO&INPIT