MODEL SYSTEMS AND TREATMENT REGIMES FOR TREATMENT OF NEUROLOGICAL DISEASES

摘要

PROBLEM TO BE SOLVED: To provide animal models and clinical trials for assessing agents with a potential use in the treatment and effective prophylaxis for stroke and other neurological diseases, particularly those mediated at least in part by excitotoxicity.SOLUTION: The invention provides a method comprising administering, to a subject having or at risk of the disease mediated by excitotoxicity, a pharmacological agent that inhibits binding of PSD-95 to NMDAR 2B and/or of PSD-95 to nNOS, wherein when the agent is a peptide having the amino acid sequence YGRKKRRQRRRKLSSIESDV, the dose is 2-3 mg/kg, and when the agent is other than the peptide having the amino acid sequence YGRKKRRQRRRKLSSIESDV, the dose delivers the equivalent effective concentration of the agent to 2-3 mg/kg of the peptide having the amino acid sequence YGRKKRRQRRRKLSSIESDV.SELECTED DRAWING: None