Combined systemic and local treatment of damaged tissue

摘要

Kits and methods for treating damaged tissue caused by viruses in mammals involve co-administration of systemic antiviral drugs and local administration of anti-infective compositions. Systemic antiviral drugs are administered internally and systemically disrupt or inhibit viral replication in mammals. Examples include nucleoside analogs, nucleoside analog precursors, and nucleotide analogs. Topically administered anti-infective compositions contain at least one anti-infective agent, such as an organic halide (eg, benzalkonium chloride), which penetrates under the damaged tissue surface and is anti-infected at the site of the damaged tissue The drug is formulated so that it can kill the virus. The anti-infective composition reduces the time and / or frequency of systemic antiviral administration necessary to treat the damaged tissue without the topical administration of the anti-infective composition. It also reduces or eliminates the occurrence of post-treatment neuralgia. [Selection] Figure 1